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The focus of this lecture is to learn about the details of the neuronal action potential. In this fashion, neurons are said to be excitable cells. The rapid reversal of membrane potential forms an important basis for information processing, propagation, and transmission and is referred to as the action potential, electrical impulse, or nervous impulse. By reversal, it is meant that the membrane potential rapidly changes from its resting level of approximately −70 mV to around +50 mV and, subsequently, rapidly returns to the resting level again. One such mechanism that is at the core of neuronal function is based on rapid and reversible reversal of the electrical potential difference across the plasma membrane. Thursday, July 5, 2012Neurons rely on a number of mechanisms to perform their important jobs of ( i) receiving information, ( ii) information processing, ( iii) signal propagation, and ( iv) signal transmission. The interactive graph provided in this tutorial allows for a good understanding of the Hill equation, how the reaction velocity changes as a function of the substrate concentration, and how changes in V max, K 0.5, and n alter the shape of the graph. Examination of reaction kinetics by using the Hill equation is useful because it reveals three important kinetic parameters: (1) the maximum rate of the reaction, also referred to as the maximum reaction velocity ( V max), (2) the half-maximal concentration constant ( K 0.5), which is the substrate concentration that gives rise to 50% V max, and (3) the Hill coefficient ( n), which provides a measure of substrate binding cooperativity. This equation is also commonly used to describe the rate of transporter-mediated translocation of ions and molecules across biological membranes. The Hill equation is often used to describe the rate of a reaction catalyzed by an enzyme as a function of the substrate concentration. Macro-to-micro illustrations help students bridge the gap between familiar and unfamiliar structures of the body by sequencing anatomical views from whole structures to their smaller parts.Wednesday, October 22, 2014The Hill equation is used to describe substrate-protein interactions that exhibit a sigmoidal shape. This approach lets students compare the illustrators' interpretations with photos of the actual structures as they might appear in the laboratory or operating room. The Focus sections at the ends of certain chapters (Focus: Cranial Nerves, for example) have been eliminated.Ĭompound art provides students with multiple views of the same structure, typically pairing a drawing by medical illustrators Bill Ober and Claire Garrison with a cadaver photograph taken by renowned biomedical photographer Ralph Hutchings. The Aging sections toward the ends of chapters have been eliminated. Selected Clinical Terminology, in the end-of-chapter material in Fundamentals of Anatomy & Physiology, has been eliminated. The Clinical Discussions and The Clinical Notes in Fundamentals of Anatomy & Physiology have been made more concise without losing any of the key clinical topics (diabetes, AIDS, cancer, etc.). For example, Chapter 10, The Muscular System, reduces the number of muscles presented, such as some of the skeletal muscles. The detail in some discussions has been reduced. The Axial Skeleton (Chapter 7) and The Appendicular Skeleton (Chapter 8) have been combined into one chapter, The Skeleton (Chapter 7), and Neural Integration I (Chapter 15) and Neural Integration II (Chapter 16) have been combined into one chapter, Neural Integration (Chapter 14). The 29 chapters in Fundamentals of Anatomy & Physiology have become 27 chapters in this slim version.
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Human Anatomy and Physiology (Two Semesters) >Īnatomy & Physiology and InterActive Physiology 8-System Suite CD-ROM Plus Access to Companion Web site.Career Readiness & Employability Skills.Pearson author roundtable on digital learning.MyLab IT: preparing students for certification.Engaging students with interactive figures.Co-requisite/Accelerated Learning Model.Choosing the Right Solutions for Your Redesign.Teacher Education & Helping Professions.Engineering, Computer Science & Programming.Using a Team-Based Approach to Learning.Downloading and using instructor resources.
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